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Another part involves using this senolytic to treat a rare, life-threatening disease for which other treatments may not be readily available

They accelerate healing - they don't replace fundamentals

This is largely controlled by a RING finger E3 ligase, MDM2 (murine double minute 2, HDM2 in human) 49

10.1016/j.neuroscience.2004.06.076 130 RashadM

These cardiovascular benefits may relate to the peptide's stress-reducing effects, since chronic stress contributes to hypertension and cardiac dysfunction

45 Although the role of each individual ROS cannot be investigated in vivo in humans, and, although superoxide anion and ONOO are the best characterized ROS, the possible role of other oxidant compounds such as hydrogen peroxide (the dismutation product of superoxide anions) and hypochlorous acid, which cannot be considered as free radicals but have a powerful oxidizing capacity, also needs to be mentioned