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Aw et al
That is a pulmonary embolus
No human clinical trials exist for TB-500
This calculus matters for conditions requiring strong systemic effects
BBB dysfunction in these pathologies may result in compromised transport and permeability properties of the barrier as well as in alterations in cerebrovascular regulatory mechanisms of blood flow, with ensuing perturbed signalling between brain endothelium and associated cells, such as glia and neurons
Notably, EC has been reported to suppress NF-B activation by inhibiting the degradation of IB, an essential inhibitory protein
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