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It mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating
The CAROLINA trial is the first active comparator CVOT in the DPP4i class and compared linagliptin to glimepiride on cardiovascular safety and non-inferiority with subsequent hierarchical testing for superiority among adults with T2DM and established CVD (34.5%) or increased cardiovascular risk factors alone, with a median follow-up of more than 6 yearsthe longest follow-up of any DPP4i studied to date
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In addition, IGF-1 LR3 may enhance tumor stem cell characteristics by inducing epithelial mesenchymal transition (EMT), leading to increased chemotherapy resistance and recurrence risk
Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction
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