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"Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin"
ITPPs action appears to be pH-dependent, showing greater activity in acidic, hypoxic environments, such as ischemic myocardium, while having minimal effect in well-oxygenated, alkaline tissues (Figure 2 for details)
References 1 ShiM-QXuYFuXPanD-SLuX-PXiaoYet al
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