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Upon confirming gastroparesis, treatment options may encompass the following approaches: Consuming smaller portions with reduced fat content for improved digestion Decreasing the pace of GLP-1 dosage escalation Using medications that support digestive function and alleviate queasiness Temporarily halting or discontinuing the GLP-1 drug completely Individual treatment responses differ, making collaboration with your healthcare team essential for identifying the optimal approach for your situation

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When a patient plateaus or fails to respond, the question shouldn't be "increase the dose?" but "what has changed metabolically?" Measuring resting energy metabolism and substrate utilisation provides a prospective way to identify metabolic adaptation, personalise nutrition, preserve lean mass and guide treatment before outcomes deteriorate

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Dosing tiers: Nasal administration provides rapid CNS penetration via the olfactory mucosa

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Madanes AE et al

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