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Blood pressure, triglycerides, LDL cholesterol, and inflammatory markers also improved significantly

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Retatrutide is an investigational triple incretin receptor agonist that simultaneously activates glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

11 In one clinical trial, the secoiridoids found in gentian, which are the compound responsible for that bitter taste, demonstrated both a higher response of GLP-1 and a significantly reduced appetite, evidenced by a 30% lower energy intake over the post-lunch period

[13] [14] It remains under clinical investigation, and any reported skin-related symptoms should be interpreted within the context of emerging, rather than fully established, evidence