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Removal of extracellular Ca 2+ abolished DEET-induced Fluo3 fluorescence but had no effect on annexin V binding

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8 A growing body of evidence has shown that regeneration and maintenance of the cellular NADP(H) content is strongly implicated in a variety of pathological conditions, such as diabetes, cardiovascular disease, neurodegenerative diseases, aging, 4,5 especially in tumorigenesis and cancer progression

doi:10.1101/2023.11.20.567908

At the same time, a vitamin B12 deficiency is only one possible contributor toward an iron deficiency

Human studies have also confirmed the relationship between BH 4 depletion and endothelial dysfunction