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Particular attention should be paid to other diabetes medications (especially insulin or sulfonylureas, which may require dose adjustment), and medications that affect gastric emptying
Linking these cellular effects to imaging markers of plaque stability may clarify how GLP-1RAs reduce rupture risk and acute coronary events
Results published in The Lancet showed significant improvements in both weight and glycemic control (Rosenstock et al., 2023): Participants lost up to 16.9% of body weight (lower than the non-diabetic cohort, consistent with other medication studies) HbA1c reductions of up to 2.02 percentage points , bringing many participants into the normal range Significant improvements in fasting glucose and insulin sensitivity Phase 3 Trials Eli Lilly initiated Phase 3 clinical trials for retatrutide in late 2023
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