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(This brief focuses on actions at the federal level and does not address state legislative efforts related to PBMs, which have occurred in all 50 states.) The Role of PBMs Pharmacy benefit managers (PBMs) act as intermediaries between drug manufacturers and insurance companies that offer drug benefits to employer health plans, Medicare Part D prescription drug plans, state Medicaid programs, and other payers

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Across the trials, effect sizes differ by peptide class, dosage, and treatment duration, with the most consistent improvements observed in metabolic indicators, such as fasting glucose levels and HOMA-IR, and body composition

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