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In the present study, low GSH-elicited CYP2E1 induction did not exacerbate liver damage or steatosis following chronic ethanol feeding

HO-1 catalyzes the rate-limiting step in the catabolism of heme into biliverdin, carbon monoxide (CO) and iron

The administration of hemin results in the boost of HO-1 expression and mitigates inflammatory responses in retinal ganglion cell injury in diabetic retinopathy, as well as diabetic wound healing, diabetic kidney function and [54,55,56]

These effects are observed in experimental settings, but there is no established safe dose for human use from clinical trials

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