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95% CI, 1.412.75) in the CANVAS CVOT, which overall included 10,142 patients with T2DM and high cardiovascular risk [75]
GLP-1 (glucagon-like peptide-1) medications are now recognized as effective treatments for PCOS, particularly in aiding weight loss and regulating metabolic health
On testing cadence, note that there is no universal evidence-based schedule: the frequency of laboratory monitoring should be individualized according to the therapy being used, underlying medical conditions, treatment response, and current clinical guidelines
It works on two hormonal pathways, improving insulin activity and helping reduce food cravings
General approach: If on Semaglutide 0.5 mg or less: Start tirzepatide at 2.5 mg If on Semaglutide 1.0 mg: Start tirzepatide at 5 mg If on Semaglutide 1.7-2.4 mg: Start tirzepatide at 5-7.5 mg Some providers start everyone at 2.5 mg regardless of previous dose to minimize side effects
Similarly, cholecystitis rates were approximately 0.6% with semaglutide compared to 0.2% with placebo
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