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In HFD-fed mice with a genetically determined increase in MAIT cells, reduced hepatic lipid accumulation and lower expression of lipogenic genes suggested a protective role for these cells during the early stages of disease (159)
If inflammation is part of the research question, KPV's anti-inflammatory mechanism is directly relevant
In individuals with obesity without T2DM, SURMOUNT- 1 evaluated the safety and effectiveness of tirzepatide 5, 10, and 15 mg once weekly in comparison to a placebo when paired with a 500 kcal/day deficit diet and recommendations for 150 min of weekly exercise [118]
JOE ROGAN: I think part of it is tension
doi:10.3390/ijms19071987 Wang X, Liu B, Xu Q, et al
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