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38 reported a decreasing trend in the ACC and a reduction in the orbitofrontal cortex

Thus, the study likely includes patients with relatively small infarcts, which is not reflective of the general STEMI population

Every patient is different

A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

The FDA does not standardize any dosage for lipotropic injections

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