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Diagnostic criteria include bilateral symmetrical fat deposition, sparing of hands/feet, tenderness to palpation, easy bruising, and resistance to diet/exercise Document your treatment history: what you have tried (diets, exercise, compression, manual lymphatic drainage, other medications) and the results Explain why tirzepatide's dual mechanism may offer advantages over GLP-1-only options for your specific condition Request baseline measurements: perometry or water displacement volumetry of affected limbs, pain scores, and metabolic labs Agree on a monitoring timeline with your provider, typically assessments every 3 months with limb measurements and pain evaluation Frequently Asked Questions Is tirzepatide better than semaglutide for lipedema

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