Surrogate endpoints and health technology assessment: a review of methodological considerations
doi: 10.3389/fendo.2026.1747766 Received 17 November 2025 Revised 15 March 2026 Accepted 24 March 2026 Published 13 April 2026 Volume 17 - 2026 Edited by Borehalli Mayegowda Shilpa, Christ University, India Reviewed by Avi Lerner, Imperial College London, United Kingdom Jelina Basnet, University of Mississippi Medical Center, United States Updates Copyright 2026 Du, Su, Huang, Liu, Li, Yang, Tao and Li
A Deeper Look at the Cellular Mechanisms and Signaling Pathways At the level of intestinal L cells, GLP-1 secretion is orchestrated through a sophisticated array of receptor-coupled signaling cascades
On the other hand, it has also been suggested that pancreatic-derived GLP-1 may play a role even under normal circumstances
Obstructive sleep apnea In late 2024, Zepbound received FDA approval for obstructive sleep apnea
For some kind of comparison, we can look at the US, by far the worlds largest semaglutide market