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Retatrutides triple-receptor mechanism addresses appetite suppression through GLP-1, nutrient partitioning through GIP, and direct fat mobilization through glucagon activation
The FDAs phrasing is not accidental
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The authors call for long-term studies to assess the impact of GLP-1 RAs on cardiovascular safety, bone health, growth, pubertal development, and other long-term outcomes, helping define their role in the long-term management of pediatric metabolic disease
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