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9 Accordingly, much of the field has focused on intracellular determinants of susceptibility, including cellular iron handling, glutathione metabolism, the remodeling of polyunsaturated fatty acid (PUFA)-containing phospholipids, and both glutathione peroxidase 4 (GPX4)-dependent and GPX4-independent antioxidant defense pathways

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Studies on how IGF-1 and other growth factors influence muscle adaptation can lead to new approaches for enhancing muscle function and preventing injuries

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