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[Diagram suggestion: three-column flowchart showing Phase 1 "GI Adaptation," Phase 2 "Appetite Suppression Plateau," and Phase 3 "Therapeutic Dose," with decision gates between each phase] Phase 1: GI Adaptation (weeks 1-2 at each new dose) The first two weeks after any dose increase are dominated by GI side effects

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While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met [1]

Mutations in the GCKR and MBOAT7 genes are also linked to MASLD