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Both GIP and GLP-1 receptors are found in brain areas important for appetite regulation.31 Tirzepatide incorporates the GLP-1 actions described above

Participants were randomized in a 2:1:1:1:1:2:2 ratio to once-weekly subcutaneous retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, over a 48-week treatment period

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Metformin as a Maintenance Option Metformin, a well-established medication for type 2 diabetes, can be considered as a maintenance option post-GLP-1

Mavlyutov TA, Epstein ML, Liu P, Verbny YI, Ziskind-Conhaim L, Ruoho AE