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However, GLP-1 agonists have limitations
REDEFINE-4 showed 23.0% weight loss at 84 weeks head-to-head against tirzepatide (Zepbound), which produced 25.5%
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They've optimized foundational interventions, sleep, nutrition, training, and stress management to the extent possible
Excessive injection site reactions Persistent or severe injection site reactions warrant investigation
That distinct mechanism is exactly why it is discussed as a complement to GLP-1 or GIP/GLP-1 agonists rather than a substitute
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