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In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

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Both compounds require gradual titration to allow GI tolerance to build

Exercise selection matters too

But semaglutide may impact how your body responds to alcohol

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