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Key points: Gastrointestinal side effects became more common as the dose rose in STEP UP, from 42.8% on placebo to 61.2% on 2.4 mg and 70.8% on 7.2 mg Altered skin sensations, such as tingling, were also more common on 7.2 mg (22.9%) than on 2.4 mg (6.0%) Nausea, diarrhoea, vomiting, and constipation are the most common side effects Side effects are usually worst just after a dose increase and often settle within a few weeks Its worth considering whether increasing the dose is worth the risk of increased side effects

Further information on lipohypertrophy and site rotation is available from Diabetes UK and the Forum for Injection Technique UK (FIT UK)

obesity is not a temporary problem, said Dorothea Vafiadis, a senior strategist for healthy aging at the National Council on Aging

As with any probiotic, individuals with compromised immune systems or specific health conditions should consult a healthcare professional before use