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Clinical trials define constipation strictly, typically as fewer than three bowel movements per week
One promising area of regenerative medicine for gut repair is peptide therapy specifically, BPC-157 and KPV , two small protein fragments that support tissue healing and inflammation control at a cellular level
Dose escalation is not always better starting low (300 mcg) and adjusting as needed is recommended
Across hundreds of animal studies, serious adverse effects have not been commonly reported
Collagen type III and fibronectin were also detected at very low levels in controls matrices, and found not to significantly change upon LOX/BMP1 treatments
Nat Rev Cancer (2012) 12(8):56471
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