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Acknowledgements This study was supported by grants from the Tokyo Metropolitan Government and the Japan Agency for Medical Research and Development

At the same time, the liposome technology helps protect glutathione as it passes through the digestive system, allowing better utilisation in the body

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Glossary T2DM Type 2 Diabetes Mellitus DM Diabetes mellitus IDF International Diabetes Federation IR Insulin Resistance DAG diacylglycerol IL-17 Interleukin-17 IL-6 Interleukin-6 SOCS-3 Cytokine signaling inhibitors IL-1 Interleukin-1 IL-18 Interleukin-18 NF- Tumor Necrosis Factor alpha NF-Bp65 Nuclear Factor-Bp65 TSOD T2DM mice TSNO Non-T2DM mice SCFA Short-Chain Fatty Acid GPR43/41 G protein-coupled receptor43/41 GLP-1 Glucagon-like peptide-1 ROS reactive oxygen species NF-B oxidative stress induces nuclear factor B SAPK stress-activated protein kinase p38MAPK p38 mitogen-activated protein kinase PDX-1 Pancreatic and Duodenal Homeobox one FOXO Forkhead box protein O transcription factor MafA Transcription factor A DAG diacylglycerol PINK1/Parkin Homologous phospho-tensin-inducible kinase 1/parkinson protein PI3K/AKt Phosphatidylinositol 3-kinase/protein kinase B GLUT4 Glucose transporter protein 4 PI3K Phosphatidylinositol 3-kinase IRS, IRS-1 Insulin receptor substrate

In this article, we will explore the benefits of glutathione for the skin, including its role in brightening and whitening, anti-aging, antioxidant protection, and more