This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation
Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas
AKG, a TCA cycle metabolite, is a required cofactor for the histone demethylase JHDM and the DNA demethylase TET, and a reduction in Gln-dependent aKG production inhibits the activity of histone and DNA demethylases, which regulate numerous cancer-related genes 40,41
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