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Vomiting, constipation, and injection site reactions rounded out the most frequent adverse events

When GLP-1 medications suppress saliva production, that entire defence system begins to fail

Semaglutide generally produces greater metabolic improvement, but metformin remains valuable: Much lower cost makes it accessible regardless of insurance Decades of safety data Can be combined with semaglutide for enhanced effect Appropriate first-line option when cost is prohibitive Many providers use both medications, starting metformin for initial treatment and adding semaglutide when additional improvement is needed or when weight loss is a priority

Results showed superior glycemic control with oral semaglutide compared with placebo, supporting its potential clinical utility in this population

Everyone responds differently, and feeling fine is a good thing, not something to worry about