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The IGF-1 Receptor and PI3K/Akt/mTOR Pathway When IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R) on a target cell, it activates a signaling cascade beginning with PI3K, which in turn activates Akt, ultimately converging on mTOR a master regulator of cell growth and protein synthesis
J Clin Endocrinol Metab (2010) 95:2497502.10.1210/jc.2009-2247 48 LuqueRMIbez-CostaANetoLVTaboadaGFHormaechea-AgullaDKasukiLet alTruncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas
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