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For clinicians, GLP-1 RAs may be a pragmatic consideration in HS management where weight loss is a goal and comorbid metabolic risk is present, pending confirmatory evidence

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This hypothesized systemic dissemination of inflammation constitutes the mechanistically plausible pathophysiological bridge between testicular dysfunction and penile ED, a mechanism that has long been underrecognized in traditional research focusing solely on local testicular changes (204)

Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells