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Muscle loss makes up to 20 to 50% of weight loss it can affect the cardiovascular system, increase risk of falls and fractures and, makes it more difficult to lose weight Lon Ben-Asher, Registered Dietitian and Pritikin Educator To mitigate muscle loss during weight loss, clinical guidelines recommend adopting healthy lifestyle habits that include exercise and an eating plan that focuses on water-rich, nutritious, whole foods with sufficient protein

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The preservative in the medication helps slow bacterial growth, but it only works for a limited time

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Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds