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Clinical trials show that tirzepatide produces 20-25% more weight loss than semaglutide in some populations, particularly those with genetic variations that blunt GLP-1-only response
Ceriello 2010
Dehydration Reduced appetite may also decrease fluid intake, and gastrointestinal side effects can lead to fluid losses
Repeated flares not only degrade organ efficiency but also affect the energy and quality of digestion
Certain groups may be more vulnerable to the effects of muscle loss: Older adults Individuals with low baseline muscle mass People who are physically inactive Women in perimenopause or postmenopause In these populations, muscle loss can contribute to sarcopenia (age-related muscle decline) and increase the risk of falls, frailty and reduced independence
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