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Kattakuzhy, who is also the associate director of the Kahlert Institute for Addiction Medicine at UMSOM, describes the design of the STAC Study, which is evaluating the safety and tolerability of semaglutide in people with cocaine use disorder, including participants with and without HIV, while also tracking secondary outcomes such as changes in drug use and cravings

This upregulation was achieved by elevated levels of ERK, c-Fos, NF-B p65, NF-B p50, and CUX1, all factors known to bind to the promotor of TNF and IL-6 (180)

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