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Sato Y, Yamaguchi Y, Kawamoto T, et al
Roughly 18-22% of patients report no subjective benefit
Frozen medication should be discarded
Cardiovascular Evidence: SELECT Trial Beyond weight loss, semaglutide demonstrated direct cardiovascular protection in the SELECT trial the largest cardiovascular outcomes trial ever conducted in an obesity population
Sabuhi R et al
Given tirzepatide's demonstrated efficacywith weight loss exceeding that achieved with other approved medications there is no evidence of additional benefit from adding lipotropic injections , and this combination is not endorsed by clinical guidelines
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