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For instance, PAGln significantly alleviates doxorubicin-induced cardiac toxicity via gut microbial metabolism regulation, reverses abnormal myocardial gene expression (e.g., Klb, Ece2, Casq1), and mitigates myocardial injury and apoptosis through mechanisms involving lipid metabolism, calcium signaling pathways, and store-operated Ca 2+ channel activity (Huang et al., 2025)
In the first 24 to 48 hours, many patients notice subtle changes in appetite and satiety
Physiology, obesity, neurohormonal appetite, and satiety control
J Biol Chem (2005) 280:27508.10.1074/jbc.M410242200 41 Gonzalez-DosalRHoranKARahbekSHIchijoHChenZJMieyalJJet alHSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6
Strengths and limitations The authors describe this as the first study to examine obesity treatment uptake in detail, combined with the direction of weight change during and after discontinuation
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