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GLP-1 signaling reduces appetite and modulates reward, while GIP signaling enhances metabolic regulation and may have central nervous system effects

A small amount of the medication can still be present in your body up to 5 weeks after taking your last dose

If you have conditions like irritable bowel syndrome (IBS) or gastroparesis, these side effects could be more severe

Use with caution in patients with phenylketonuria

5 These guidelines align with the American Diabetes Association (ADA) standards of care which also provide strong recommendations based on robust clinical trial data supporting the cardiovascular benefits of GLP-1 RAs, particularly in patients with established cardiovascular disease and chronic kidney disease (CKD)

This is the key reason for the interest in the drug