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Pregnant people should also avoid high doses, which have been shown to cause miscarriage in animal studies and Another issue with saffron, especially saffron powder, is that it may be mixed with other ingredients, such as beet, red-dyed silk fibers, turmeric, and paprika

Melasma can be treated by drugs that inhibit melanin production by decreasing new melanin-producing cells and decreasing the proliferation of melanocytes

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