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A BMI of 30 or higher (clinically classified as obesity)

Countries with higher obesity rates and better access to these therapies will likely experience greater improvements in mortality

People new to GLP-1 agonists If retatrutide is your first exposure to any GLP-1 receptor agonist, start at the lowest practical dose

*Correspondence: Xuezhong Gong, [email protected] This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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