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The SURPASS clinical trial program (type 2 diabetes) and SURMOUNT program (obesity/overweight) together represent one of the largest phase 3 development programs in metabolic medicine

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Nausea is a recognised and manageable side effect of this class of medicines

Semaglutide side effects Side effects from using semaglutide include: Low blood sugar (in people with T2DM) Stomach upset Nausea, vomiting Loss of appetite Diarrhea Constipation Headache Dizziness Tiredness You may also experience heartburn, burping, gas, and bloating

Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus : a 1-year , randomized controlled trial

We have also addressed the problem of the speculative nature of the paper, which is also discussed below