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This review integrates current knowledge of the mechanisms linking perioperative mitochondrial dysfunction to immune dysregulation, and systematically evaluates emerging therapeutic strategies, including mitochondrial-targeted antioxidants, permeability transition pore inhibitors, metabolic reprogramming agents, mitochondrial transplantation, and gene-based interventions

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Overnight (22:0010:00 h) fasting blood glucose (FBG) was measured with an Accu-Chek reflectance meter with Accu-Chek active test strips (Roche Diabetes Care, Mannheim, Germany) on experimental days P7, P14, P21, P28, and P38

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