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However, there has been debate as to whether L-C can provide benefit to individuals with cardiovascular disease, and its effects remain unknown with no randomized controlled trials assessing direct effects on human atherosclerosis to date
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At maximum doses, the two medications now produce very similar results: Wegovy 7.2 mg: 20.7% average weight loss (STEP UP trial) 2 Mounjaro 15 mg: 20.2% average weight loss (SURMOUNT-5 trial) 1 This means that if maximum weight loss is your primary goal, both medications can now achieve comparable results when used at their highest doses
Abbott, K.L., Friday, B.B., Thaloor, D., Murphy, T.J
Switching from Semaglutide GLP-1 to tirzepatide can offer enhanced weight loss results, improved medication adherence, and better management of comorbidities
They are not direct substitutes
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