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At patient request, we can discuss the use of topical numbing cream prior to the injection

doi:10.1016/j.jaad.2020.07.087

They target healing through different but complementary pathways

Recommended Protocol for Post-Weight-Loss Skin Tightening Dosage: 2 mg daily subcutaneous injection Cycle length: 10 to 12 weeks Rest period: 4 to 6 weeks between cycles Injection sites: Rotate between abdomen, upper arms, and thighs Optional addition: Topical GHK-Cu serum (0.5 to 1%) applied to problem areas Cycles per year: 2 to 3 Subcutaneous injection is the preferred route for skin applications because it provides near 100% bioavailability and allows for easy self-administration using 29 to 31 gauge insulin syringes at a 45 to 90 degree angle

Circulation 113 , 898918 (2006)

It did not test this subcutaneous schedule