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In clinical studies, participants typically used semaglutide for at least 68 weeks (about 16 months) to achieve significant and sustained weight loss

Cramer JA, Mintzer S, Wheless J, Mattson RH

Acute Kidney Injury Due to Volume Depletion: There have been postmarketing reports of acute kidney injury, in some cases requiring hemodialysis, in patients treated with GLP-1 receptor agonists

The Role of Personalized Programs One of the challenges of traditional weight loss is the one-size-fits-all approach

The addition of glucagon receptor agonism introduces theoretical concerns about hepatic glucose output, though no clinically significant hyperglycemia was observed