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doi:10.1007/s12010-015-1840-7 Destoumieux D, Bulet P, Loew D, Van Dorsselaer A, Rodriguez J, Bachere E
Healthcare providers should ensure appropriate documentation, informed consent, and risk mitigation strategies
The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination
This landmark study remains one of the strongest demonstrations of a neuropeptide's sleep-promoting activity in preclinical models Eur J Neurosci (2007) -- further characterization of cortistatin's sleep neurobiology, confirming the initial findings Anti-inflammatory studies -- cortistatin has demonstrated potent anti-inflammatory effects in multiple preclinical models (IBD: PNAS 2006, sepsis: J Leukoc Biol 2006, arthritis, atherosclerosis)
Cellular migration is essential for tissue repair
many of these drugs are also approved in other countries, but may have different indications and costs
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