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Current clinical data indicate that GLP-1R agonists reduce BP in diabetic patients (92) and the antihypertensive effect can also be observed in Dahl salt-sensitive rats (93), in Ang II -induced hypertension rats (91) and SHRs rats (94)
The glucagon component appears to preferentially direct energy expenditure toward fat oxidation rather than muscle catabolism, especially when paired with even moderate resistance training
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It also highlights the value of treating obesity as a chronic metabolic disease instead of expecting people to rely solely on willpower and lifestyle changes to manage their condition
The recommended daily dosage is just one capsule, to be taken with food
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