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doi: 10.1002/biof.1406 167 ReedJ.BainS.KanamarlapudiV

Furthermore, in snapshots around 320450 ns, the upper half of helix I moves together with the ECD away from the orthosteric pocket of the TMD, providing enough space for binding of the GLP-1s C-terminus to the ECD as well as docking of the N-terminus of GLP-1 to the orthosteric pocket in the TMD