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Garcia-Cardena, G

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The trade-off is dramatically reduced efficacy

The nausea typically peaks within the first two weeks of starting therapy or after a dose increase

Leuk Res 1986

The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes