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NEJM 2007

Simultaneously, its GLP-1 receptor agonist activity suppresses glucagon secretion, slows gastric emptying, and promotes satiety through central nervous system pathways

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The short answer: some lean mass loss occurs, as it does with any caloric deficit, but the proportion is better than diet-alone approaches

Lilly's Triple Agonist, Retatrutide, Demonstrated Significant Reductions in A1C and Weight in First Phase 3 Trial for Treatment of Type 2 Diabetes