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Surprisingly, intervention longer than 24 weeks showed no significant effect on BMI [40]
The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism
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Increased concentrations of the IGF-1 LR3 tracer were apparently detected in specific organs, including the kidneys, ovaries, and adrenal glands, in mouse models
T2D is reported to be 814 times more prevalent in individuals with obesity compared with those with normal weight [143]
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