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The findings of this meta-analysis suggest that GLP-1 receptor agonists are not associated with an increased risk of gastrointestinal cancers and were not associated with increased gastrointestinal cancer risk and demonstrated pooled estimates below unity for colorectal and liver cancers, findings that should be interpreted as hypothesis-generating rather than confirmatory of cancer prevention (Lingvay et al., 2018

This deserves particular scrutiny because it is, from a physiological standpoint, virtually impossible to lose significant body weight without losing any muscle mass

For pancreatic cancer, large 2025 to 2026 reviews including an Annals meta-analysis found little or no increase in risk

In combination, CJC-1295 and ipamorelin stimulate GH via divergent routes