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MOTS-c acts as a metabolic coordinator, linking mitochondrial health to nuclear gene expression, a critical communication system that often fails during aging and metabolic disease
Accessed 23 June 2022
The compound RSL3, which directly inhibits GPX4, was identified as an activator of ferroptosis (3)
Gene expression was normalized via the 2 CT method, with the -actin gene used as an internal standard
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Mechanistically, retatrutide (Eli Lilly) is an agonist of the GLP-1, GIP and glucagon receptors
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