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Our data showed that, despite the higher mTORC1 signaling in Gclc -deficient FoB cells, these cells dampened antibody production and could not ensure GC formation following activation in vivo and antibody production in vitro

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doi:10.2460/javma.229.4.531

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Moreover, the cellular NAD + -level is important as it is needed as a stoichiometric co-substrate used by host cell sirtuins for SnCE1 deacetylation